The active ingredient in Phenergan is promethazine hydrochloride, which is an antihistamine that belongs to a group of medicines known as phenothiazines. When you have an allergic reaction, your body creates a natural substance called histamine. Histamine sends signals around your body that trigger symptoms of allergy, such as a runny nose or watery eyes. Antihistamines work by blocking histamine, which prevents your symptoms so you won't have to tolerate an allergic reaction.
Promethazine (the active ingredient in Phenergan) will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours. If you're taking it for a cough or cold symptoms, allergies or nausea, your symptoms should start to improve within 20 minutes. The medicine should work for around 4 to 6 hours. Please take note of dosage requirements.
Phenergan also works directly on the brain to help you feel more relaxed. Many people find Phenergan helps them when travelling with motion sickness. Phenergan Tablets are used to treat the following conditions: For short term use: to treat adults with difficulty sleeping (insomnia).
Approved by Claire Makey - Pharmacist on the 12/04/2021.
For more information, view our medical team
Common Side Effects:
Drowsiness
Dizziness
Constipation
Blurred vision
Dry mouth
Serious Side Effects:
Respiratory depression
Seizures
Severe drowsiness or weakness
Fainting
Confusion, agitation, hallucinations
Unusual or uncontrolled movements
Jaundice (yellowing of skin or eyes)
Neuroleptic malignant syndrome (high fever, muscle rigidity, altered mental status)Drugs.com
Easy bruising or bleeding
Signs of infection (fever, sore throat)
Difficulty urinating
Children Under 2 Years: Use is contraindicated due to the risk of fatal respiratory depression.
Children Aged 2–5 Years: Use with caution; the lowest effective dose should be administered.
Central Nervous System Depression: Not recommended for individuals with a history of CNS depression.
Asthma and Respiratory Conditions: Should be avoided in patients with asthma or other respiratory diseases due to increased risk of serious adverse effects.
Pregnancy and Breastfeeding: Use only if clearly needed; consult a healthcare provider.
Alcohol Consumption: Avoid alcohol as it may enhance drowsiness and other side effects.
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